It depends on what you are using WINE for. First, you are going to have to load winesetup, the WINE graphical configuration tool. When you launch it, it will ask you to create the default config file, which will be in /home/username/.wine/config. Next, you have to tell it to use an exisiting Windows 95/98 partition, or to create a standalone WINE directory in /home/username/.wine/fake_windows. I found, on Debian at least, that it works much better to just use the Win98 partition as the system directory, and then change the AppDLLOverides in the config file after you install a windows program. This way, you will have all of the required DLLs, and you can just change the overrides in the /home/rk/.wine/config file. This page,
http://www.frankscorner.org/wine/, lists a bunch of win apps you can use, and how to override DLLs.
If you use fake_windows, you are going to have to do some searching to find DLLs that work for you.