I'm sure you all know about KMFMS and Brute!, and are probably familiar with KMFDM. Anyway, I went to see Slick Idiot last week, which includes En Esch and Gunther from KMFDM, and what did they have right on stage playing all the non-guitar and non drum audio?
An ancient PowerMac 7500 running 8.1 and a 14" Apple Color Display.
I didn't get close enough to see what they were using (Logic, Cubase, etc), but it was cool nonetheless.