I actually prefer one button when using a laptop. When I use friends' PC laptops I always accidently right click since I'm used to having my thumb positioned at the bottom-center of the trackpad on my Mac.
The only reason I use a multi-button mouse on my desktop is for gaming -- and probably the scroll wheel nowadays. One has to remember that OS X, and Mac applications, have been designed with one mouse button in mind -- so it's not like you're missing out on much.